NAD+ (Nicotinamide Adenine Dinucleotide) is a dinucleotide coenzyme essential to cellular metabolism and a substrate for several classes of regulatory enzymes. As an electron carrier in the citric acid cycle and oxidative phosphorylation, NAD+ is directly involved in ATP production in mitochondria. In its role as a substrate for sirtuins (SIRT1-7) and PARPs, it links metabolic activity to gene expression regulation, chromatin remodeling, and DNA repair — functions that have made it a central subject of aging and longevity research.

Preclinical studies have investigated the effects of NAD+ on mitochondrial function, insulin sensitivity, inflammation, and neuronal survival in animal models. Research has also examined its role in circadian rhythm regulation, with NAD+ levels demonstrating oscillation tied to the molecular clock. Studies examining CD38 as an NAD+-consuming enzyme have informed understanding of NAD+ depletion with age and in inflammatory conditions.

This 1000mg concentration is designed for research protocols requiring high-volume quantities of NAD+ for in vitro experiments, cell culture studies, or extended preclinical investigations. NAD+ is a standard research compound across biochemistry, cell biology, neuroscience, and metabolic disease research disciplines.

Disclaimer: This product is intended for in vitro research and laboratory use only. It is not intended for human or veterinary use, consumption, or injection. Not approved by the FDA. Not intended to diagnose, treat, cure, or prevent any disease or medical condition. For use by qualified researchers only.